>>259142Psilocybin induces profound, temporary, and, in some cases, lasting changes to neural pathways by acting as a serotonin receptor agonist (primarily 5-HT2A) that increases brain entropy, desynchronizes established, rigid networks, and promotes rapid structural neuroplasticity. It works by essentially "rewiring" the brain, allowing for increased connectivity between previously disconnected regions, which is believed to underpin its therapeutic, antidepressant effects.